Sionna Therapeutics Inc
SIONHealthcare·Biotechnology·USA·Micro·NASD·Nov 11 • 3:59 PM ET
Price
SION against its 20, 50 and 200-day averages93.3% under the 52-week high of 54.97 on 7 Aug 2026. 52-week low 3.19 on 6 Nov 2026. Last 15 sessions, 30.4% high to low
Volume 0.00× normal · the session has not printed · the line is the 50-bar volume average
Profile
SIONSionna Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company. The firm engages in researching, developing and commercializing novel medicines for cystic fibrosis. It is focused on advancing a pipeline of small molecules and complementary CFTR modulators designed to deliver transformative clinical outcomes and improve the quality of life for individuals living with cystic fibrosis. The company was founded by Greg Hurlbut and Mark Munson in August 2019 and is headquartered in Waltham, MA.
| Index | RUT |
|---|---|
| Employees | 59 |
| IPO | Feb 07, 2025 |
| Beta | 1.23 |
| ATR, 14d | 0.38 |
| Rel volume | 0.00 |
| Short float | 17.88% |
| Insider own | 47.89% |
| Inst own | 73.53% |
Snapshot
6 groupsValuation
| Index | RUT |
|---|---|
| Market Cap | 167.37M |
| Enterprise Value | -49.47M |
| Income | -109.52M |
| Sales | 0.00M |
| Book/sh | 5.32 |
| Cash/sh | 4.96 |
| Dividend Est. | - |
| Dividend TTM | - |
| Dividend Ex-Date | - |
| Dividend Gr. 3/5Y | - - |
| Payout | - |
| Employees | 59 |
| IPO | Feb 07, 2025 |
Ratios
| P/E | - |
|---|---|
| Forward P/E | - |
| PEG | - |
| P/S | - |
| P/B | 0.70 |
| P/C | 0.75 |
| P/FCF | - |
| EV/EBITDA | - |
| EV/Sales | - |
| Quick Ratio | 13.92 |
| Current Ratio | 13.92 |
| Debt/Eq | 0.03 |
| LT Debt/Eq | 0.03 |
| Option/Short | Yes / Yes |
Earnings
| EPS (ttm) | -2.43 |
|---|---|
| EPS next Y | -2.22 |
| EPS next Q | -0.58 |
| EPS this Y | -35.54% |
| EPS next Y | 12.70% |
| EPS next 5Y | -8.21% |
| EPS past 3/5Y | -22.66% - |
| Sales past 3/5Y | - - |
| EPS Y/Y TTM | -52.03% |
| Sales Y/Y TTM | - |
| EPS Q/Q | -57.22% |
| Sales Q/Q | - |
| Earnings | Nov 10 BMO |
| EPS/Sales Surpr. | -12.98% - |
Ownership
| Insider Own | 47.89% |
|---|---|
| Insider Trans | -15.14% |
| Inst Own | 73.53% |
| Inst Trans | 12.39% |
| ROA | -36.35% |
| ROE | -38.96% |
| ROIC | -44.37% |
| Gross Margin | - |
| Oper. Margin | - |
| Profit Margin | - |
| SMA20 | -2.00% |
| SMA50 | -26.94% |
| SMA200 | -87.06% |
| Trades | - |
Technical
| Shs Outstand | 45.21M |
|---|---|
| Shs Float | 23.56M |
| Short Float | 17.88% |
| Short Ratio | 2.83 |
| Short Interest | 4.21M |
| 52W High | 54.97 -93.27% |
| 52W Low | 3.19 15.99% |
| Volatility | 9.73% 8.46% |
| ATR (14) | 0.38 |
| RSI (14) | 36.66 |
| Beta | 1.23 |
| Rel Volume | 0.00 |
| Avg Volume | 1.49M |
| Volume | 0 |
Performance
| Perf Week | -0.80% |
|---|---|
| Perf Month | -15.53% |
| Perf Quarter | -43.43% |
| Perf Half Y | -91.42% |
| Perf YTD | -91.01% |
| Perf Year | -89.85% |
| Perf 3Y | - |
| Perf 5Y | - |
| Perf 10Y | - |
| Recom | 2.82 |
| Target Price | 15.33 |
| Prev Close | 3.70 |
| Price | 3.70 |
| Change % | 0.00% |
Analyst ratings
latest 10 of 16| Date | Action | Analyst | Rating change | Target | Implied |
|---|---|---|---|---|---|
| Aug 10, 2026 | Upgrade | RRBC Capital Mkts | Underperform → Sector Perform | $5 | +35.1% |
| Aug 10, 2026 | Downgrade | WWedbush | Outperform → Neutral | $5 | +35.1% |
| Aug 10, 2026 | Downgrade | SStifel | Buy → Hold | $7 | +89.2% |
| Aug 10, 2026 | Downgrade | RRaymond James | Strong Buy → Mkt Perform | ||
| Aug 10, 2026 | Downgrade | GGuggenheim | Buy → Neutral | ||
| Aug 10, 2026 | Downgrade | CCitizens | Mkt Outperform → Mkt Perform | ||
| Aug 10, 2026 | Downgrade | BBTIG Research | Buy → Neutral | ||
| May 05, 2026 | Initiated | WWedbush | Outperform | $53 | +1,332.4% |
| Feb 24, 2026 | Initiated | CCitizens | Mkt Outperform | $63 | +1,602.7% |
| Dec 01, 2025 | Downgrade | RRBC Capital Mkts | Sector Perform → Underperform | $24 | +548.6% |
Peers
Mkt cap| Ticker | Company | Mkt cap |
|---|---|---|
| VRTX | Vertex Pharmaceuticals Inc | 138.74B |
| INSM | Insmed Inc | 26.49B |
| SVRA | Savara Inc | 1.10B |
| AVLN | Avalyn Pharma Inc | 1.40B |
| ARMP | Armata Pharmaceuticals Inc | 144.64M |
| ELOX | Eloxx Pharmaceuticals Inc | 52.51M |
| PLRX | Pliant Therapeutics Inc | 48.15M |
| RARE | Ultragenyx Pharmaceutical Inc | 1.68B |
| MIST | Milestone Pharmaceuticals Inc | 82.44M |
| ZVRA | Zevra Therapeutics Inc | 720.01M |
Insider trading
latest 14 of 81| Insider | Relationship | Date | Transaction | Cost | Shares | Value | Total held | Form |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Director | Sep 17 '26 | Sale | 6.33 | 3,448,811 | 21,835,018 | 3,448,812 | Sep 21 06:56 PM |
| RA Capital Healthcare Fund, L. | Director | Sep 17 '26 | Proposed Sale | 6.33 | 3,448,811 | 21,834,318 | Sep 17 05:10 PM | |
| Thompson Peter A. | Director | Jul 07 '26 | Sale | 44.86 | 85,918 | 3,854,281 | 2,469,959 | Jul 09 04:47 PM |
| ORBIMED ADVISORS LLC | Director | Jul 07 '26 | Sale | 44.86 | 85,918 | 3,854,281 | 2,469,959 | Jul 09 04:44 PM |
| Fitzpatrick Jennifer | Chief Legal Officer | Jul 06 '26 | Option Exercise | 6.11 | 10,250 | 62,628 | 10,250 | Jul 07 04:38 PM |
| Fitzpatrick Jennifer | Chief Legal Officer | Jul 06 '26 | Sale | 43.60 | 10,250 | 446,862 | 0 | Jul 07 04:38 PM |
| JENNIFER FITZPATRICK | Officer | Jul 06 '26 | Proposed Sale | 43.99 | 10,250 | 450,898 | Jul 06 04:39 PM | |
| Thompson Peter A. | Director | Jun 30 '26 | Sale | 45.50 | 115,844 | 5,270,902 | 2,555,877 | Jul 02 04:45 PM |
| ORBIMED ADVISORS LLC | Director | Jun 30 '26 | Sale | 45.50 | 115,844 | 5,270,902 | 2,555,877 | Jul 02 04:42 PM |
| Thompson Peter A. | Director | May 27 '26 | Sale | 44.49 | 101 | 4,493 | 2,671,721 | May 29 09:02 PM |
| ORBIMED ADVISORS LLC | Director | May 27 '26 | Sale | 44.49 | 101 | 4,493 | 2,671,721 | May 29 08:57 PM |
| OrbiMed Private Investments VI | Shareholder | May 29 '26 | Proposed Sale | 42.80 | 1,082,480 | 46,330,144 | May 29 06:44 PM | |
| Thompson Peter A. | Director | May 11 '26 | Sale | 46.22 | 184,639 | 8,534,015 | 2,671,822 | May 11 07:14 PM |
| Thompson Peter A. | Director | May 08 '26 | Sale | 44.58 | 59,767 | 2,664,413 | 2,856,461 | May 11 07:14 PM |
Held by
AUM| Ticker | Company | AUM |
|---|---|---|
| VTI | Vanguard Morningstar Total Stock Market ETF | AUM: 687.42B |
| IWM | iShares Russell 2000 Index Fund | AUM: 77.38B |
| VXF | Vanguard Extended Market Index ETF | AUM: 30.47B |
| IBB | iShares Biotechnology ETF | AUM: 11.36B |
| IWO | iShares Russell 2000 Growth ETF | AUM: 14.06B |
| VTWO | Vanguard Russell 2000 Index ETF | AUM: 16.75B |
| SCHA | Schwab U.S. Small-Cap ETF | AUM: 22.25B |
| VHT | Vanguard Health Care ETF | AUM: 21.51B |
| SBIO | ALPS Medical Breakthroughs ETF | AUM: 192.65M |
| VTWG | Vanguard Russell 2000 Growth Index ETF | AUM: 1.41B |
News
latest 14 of 120- Sionna Therapeutics Reports Third Quarter 2026 Financial Results (GlobeNewswire)
- Sionna Therapeutics to Participate in Upcoming November 2026 Investor Conferences (GlobeNewswire)
- Sionna Therapeutics to Present Data at the 2026 North American Cystic Fibrosis Conference (GlobeNewswire)
- These beaten-down stocks could bounce back in January, if history is any guide (MarketWatch)
- FDA clears first generic radioligand drug; Sionna turns to layoffs (BioPharma Dive) -16.71%
- Sionna Therapeutics Announces Plans to Advance SION-451 + SION-2222 Dual Combination into Phase 2a Proof-of-Concept Trial (GlobeNewswire) +5.22%
- Robbins LLP Reminds Stockholders it is Investigating the Recent Stock Drop of Sionna Therapeutics (PR Newswire) +5.22% -11.68%
- Robbins LLP is Investigating the Recent Stock Drop of Sionna Therapeutics; Contact the Firm for Information (Business Wire) -8.51%
- Sionna Therapeutics stock falls 92% after SION-719 trial failure (Quartz) +13.33%
- Immunic appoints Elena Ridloff to board of directors (Proactive) -91.18%
- Why Sionna Therapeutics Stock Is Crashing 91% to a Record Low (Barrons.com)
- SION Stock On Track For Worst Day Ever After 90% Drop Whats Driving The Selloff? (Stocktwits)
- Vertex Stock Jumps 5.9% as Rival Cystic Fibrosis Drug Fails (GuruFocus.com)
- Tenax, Sionna Shares Sink After Trial Failures (The Wall Street Journal)
Quarterly earnings
actual against estimate| Period | Reported | EPS act | EPS est | EPS rep | Sales act | Sales est | Analysts |
|---|---|---|---|---|---|---|---|
| 2026Q3 | 2026-11-10 | -0.720 | -0.637 | -0.720 | 0.00 | 0.00 | 11 |
| 2026Q2 | 2026-08-06 | -0.660 | -0.650 | -0.662 | 0.00 | 0.00 | 11 |
| 2026Q1 | 2026-05-12 | -0.600 | -0.514 | -0.594 | 0.00 | 0.00 | 10 |
| 2025Q4 | 2026-03-02 | -0.460 | -0.539 | -0.457 | 0.00 | 0.00 | 10 |
| 2025Q3 | 2025-11-05 | -0.460 | -0.484 | -0.456 | 0.00 | 0.00 | 7 |
| 2025Q2 | 2025-08-11 | -0.410 | -0.555 | -0.409 | 0.00 | 0.00 | 4 |
| 2025Q1 | 2025-05-12 | -0.620 | -0.448 | -0.374 | 0.00 | 0.00 | 4 |
| 2024Q4 | 2025-03-20 | -3.380 | -1.277 | -0.359 | 0.00 | 0.00 | 3 |
| 2026Q4 | - | - | -0.582 | - | - | 0.00 | 11 |
| 2027Q1 | - | - | -0.514 | - | - | 0.00 | 7 |
| 2027Q2 | - | - | -0.501 | - | - | 0.00 | 7 |
| 2027Q3 | - | - | -0.504 | - | - | 0.00 | 7 |
| 2027Q4 | - | - | -0.490 | - | - | 0.00 | 5 |
Annual earnings
| Period | EPS act | EPS est | EPS rep | Sales act | Sales est |
|---|---|---|---|---|---|
| 2024FY | -15.990 | -5.263 | -1.398 | 0.00 | 0.00 |
| 2025FY | -1.880 | -1.996 | -1.880 | 0.00 | 0.00 |
| 2026FY | - | -2.548 | - | - | 0.00 |
| 2027FY | - | -2.225 | - | - | 0.00 |
| 2028FY | - | -2.382 | - | - | 1.67 |
| 2029FY | - | -2.450 | - | - | 27.60 |
| 2030FY | - | -2.264 | - | - | 58.26 |
Estimate revisions
last 14 periods| Period | Type | Date | Estimates | Up | Down | Mean | Low | High |
|---|---|---|---|---|---|---|---|---|
| 2026Q4 | S | 2026-11-10 | 8 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-08-06 | 8 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-07-23 | 8 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-06-10 | 7 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-05-12 | 8 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-05-01 | 8 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-03-05 | 7 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-03-04 | 6 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-03-02 | 5 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2026-02-23 | 3 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2025-11-12 | 2 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2025-11-11 | 2 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | S | 2025-11-10 | 2 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| 2026Q4 | R | 2026-11-10 | 6 | 1 | 4 | -0.58 | -0.73 | -0.43 |
Estimate history
| EPS, annual | -0.912 | -1.071 | -1.398 | -1.683 | -2.4301 | ||||
|---|---|---|---|---|---|---|---|---|---|
| Period | 2022 | 2023 | 2024 | 2025 | TTM | ||||
| EPS, quarterly | -0.577 | -0.359 | -0.374 | -0.409 | -0.456 | -0.457 | -0.594 | -0.662 | -0.717 |
| Period | Q3 '24 | Q4 '24 | Q1 '25 | Q2 '25 | Q3 '25 | Q4 '25 | Q1 '26 | Q2 '26 | Q3 '26 |
| Sales, annual | 0 | 0 | 0 | 0 | 0 | ||||
| Period | 2022 | 2023 | 2024 | 2025 | TTM | ||||
| Sales, quarterly | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Period | Q3 '24 | Q4 '24 | Q1 '25 | Q2 '25 | Q3 '25 | Q4 '25 | Q1 '26 | Q2 '26 | Q3 '26 |
| Shares, annual | 44.124 | 44.124 | 44.124 | 44.724 | 45.214 | ||||
| Period | 2022 | 2023 | 2024 | 2025 | MRQ | ||||
| Shares, quarterly | 44.124 | 44.124 | 44.092 | 44.132 | 44.464 | 44.724 | 45.076 | 45.164 | 45.214 |
| Period | Q3 '24 | Q4 '24 | Q1 '25 | Q2 '25 | Q3 '25 | Q4 '25 | Q1 '26 | Q2 '26 | Q3 '26 |
Income statement, annual
| Metric | TTM | 2025FY | 2024FY | 2023FY | 2022FY |
|---|---|---|---|---|---|
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cost of Goods Sold Incl. D&A | 0.61 | 0.65 | 0.67 | 0.58 | 0.12 |
| Gross Profit | -0.61 | -0.65 | -0.67 | -0.58 | -0.12 |
| Selling, General and Administrative Excl. Other | 113.69 | 88.33 | 69.89 | 49.75 | 41.25 |
| Research and Development | 74.32 | 60.26 | 57.29 | 40.63 | 34.60 |
| Other Operating Expense | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Operating Income | -114.30 | -88.98 | -70.56 | -50.33 | -41.37 |
| Interest Expense | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Unusual Expense | 6.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| Net Income Before Taxes | -109.52 | -75.27 | -61.69 | -47.26 | -40.24 |
| Income Taxes | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Consolidated Net Income | -109.52 | -75.27 | -61.69 | -47.26 | -40.24 |
| Net Income From Continuing Operations | -109.52 | -75.27 | -61.69 | -47.26 | -40.24 |
| Net Income | -109.52 | -75.27 | -61.69 | -47.26 | -40.24 |
| EPS (Recurring) | -2.33 | -1.68 | -1.40 | -1.07 | -0.91 |
| EPS (Basic, Before Extraordinaries) | -2.43 | -1.68 | -1.40 | -1.07 | -0.91 |
| EPS (Diluted) | -2.43 | -1.68 | -1.40 | -1.07 | -0.91 |
| EBITDA | -113.69 | -88.33 | -69.89 | -49.75 | -41.25 |
| Non-Operating Income (Expense) | 10.98 | 13.71 | 8.87 | 3.07 | 1.13 |
| Other After Tax Adjustments | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Stock Option Compensation Expense | 24.30 | 12.07 | 3.71 | 2.26 | 1.69 |
| Shares Outstanding | 45.21 | 44.72 | 44.12 | 44.12 | 44.12 |
| Market Capitalization | 167.29 | 167.29 | 1,847.19 | - | - |
Income statement, quarterly
| Metric | 2026Q3 | 2026Q2 | 2026Q1 | 2025Q4 | 2025Q3 | 2025Q2 | 2025Q1 | 2024Q4 |
|---|---|---|---|---|---|---|---|---|
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cost of Goods Sold Incl. D&A | 0.15 | 0.15 | 0.15 | 0.15 | 0.10 | 0.15 | 0.16 | 0.17 |
| Gross Profit | -0.15 | -0.15 | -0.15 | -0.15 | -0.10 | -0.15 | -0.16 | -0.17 |
| Selling, General and Administrative Excl. Other | 28.46 | 32.31 | 29.45 | 23.46 | 23.70 | 21.76 | 19.50 | 17.97 |
| Research and Development | 18.32 | 21.86 | 18.96 | 15.17 | 16.04 | 15.38 | 13.67 | 14.25 |
| Other Operating Expense | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Operating Income | -28.62 | -32.47 | -29.60 | -23.61 | -23.80 | -21.91 | -19.66 | -18.13 |
| Interest Expense | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Unusual Expense | 6.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Net Income Before Taxes | -32.42 | -29.89 | -26.78 | -20.44 | -20.28 | -18.07 | -16.48 | -15.85 |
| Income Taxes | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Consolidated Net Income | -32.42 | -29.89 | -26.78 | -20.44 | -20.28 | -18.07 | -16.48 | -15.85 |
| Net Income From Continuing Operations | -32.42 | -29.89 | -26.78 | -20.44 | -20.28 | -18.07 | -16.48 | -15.85 |
| Net Income | -32.42 | -29.89 | -26.78 | -20.44 | -20.28 | -18.07 | -16.48 | -15.85 |
| EPS (Recurring) | -0.62 | -0.66 | -0.59 | -0.46 | -0.46 | -0.41 | -0.37 | -0.36 |
| EPS (Basic, Before Extraordinaries) | -0.72 | -0.66 | -0.59 | -0.46 | -0.46 | -0.41 | -0.37 | -0.36 |
| EPS (Diluted) | -0.72 | -0.66 | -0.59 | -0.46 | -0.46 | -0.41 | -0.37 | -0.36 |
| EBITDA | -28.46 | -32.31 | -29.45 | -23.46 | -23.70 | -21.76 | -19.50 | -17.97 |
| Non-Operating Income (Expense) | 2.40 | 2.58 | 2.82 | 3.17 | 3.53 | 3.84 | 3.18 | 2.29 |
| Other After Tax Adjustments | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Stock Option Compensation Expense | 7.08 | 6.84 | 6.55 | 3.83 | 3.31 | 2.84 | 2.09 | 1.06 |
| Shares Outstanding | 45.21 | 45.16 | 45.08 | 44.72 | 44.46 | 44.13 | 44.09 | 44.12 |
| Market Capitalization | 167.29 | 1,986.16 | 1,803.97 | 1,836.03 | 1,298.15 | 765.56 | 461.54 | 510.08 |
Balance sheet, annual
| Metric | 2025FY | 2024FY | 2023FY | 2022FY |
|---|---|---|---|---|
| Cash & Short Term Investments | 235.88 | 147.54 | 38.52 | 82.61 |
| Short Term Receivables | 0.00 | 0.00 | 0.00 | 0.00 |
| Inventories | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Current Assets | 5.54 | 3.46 | 0.69 | 1.22 |
| Total Current Assets | 241.42 | 150.99 | 39.21 | 83.83 |
| Net Property, Plant & Equipment | 9.15 | 10.30 | 11.73 | 2.57 |
| Total Investments and Advances | 75.38 | 21.47 | 0.96 | 0.96 |
| Intangible Assets | 0.00 | - | - | 0.00 |
| Deferred Tax Assets | 1.98 | - | - | - |
| Other Assets | 0.00 | 2.99 | 0.04 | 0.00 |
| Total Assets | 327.93 | 185.75 | 51.95 | 87.37 |
| Short Term Debt Incl. Current Port. of LT Debt | 1.27 | 1.07 | 0.73 | 0.00 |
| Accounts Payable | 0.77 | 1.19 | 0.72 | 0.56 |
| Other Current Liabilities | 9.67 | 8.16 | 6.59 | 7.70 |
| Total Current Liabilities | 11.71 | 10.42 | 8.04 | 8.25 |
| Long Term Debt | 7.41 | 8.68 | 9.75 | 0.00 |
| Provision for Risks Charges | 0.00 | 0.00 | 0.00 | 0.00 |
| Deferred Tax Liabilities | 1.98 | - | - | - |
| Other Liabilities | 0.00 | 0.00 | 0.00 | 0.00 |
| Total Liabilities | 21.10 | 19.10 | 17.79 | 8.25 |
| Non-Equity Reserves | 0.00 | 0.00 | 0.00 | 0.00 |
| Preferred Stock - Carrying Value | 0.00 | 330.37 | 149.04 | 149.04 |
| Common Equity | 306.83 | -163.71 | -114.88 | -69.92 |
| Total Shareholders Equity | 306.83 | 166.66 | 34.16 | 79.12 |
| Accumulated Minority Interest | 0.00 | 0.00 | 0.00 | 0.00 |
| Total Equity | 306.83 | 166.66 | 34.16 | 79.12 |
| Total Liabilities & Stockholders Equity | 327.93 | 185.75 | 51.95 | 87.37 |
| Book Value Per Share | 6.86 | -3.71 | -2.60 | -1.58 |
| Tangible Book Value Per Share | 6.86 | -3.71 | -2.60 | -1.58 |
| Full-Time Employees | 59 | 41 | 28 | - |
| Price to Book Ratio | 0.70 | 5.72 | - | - |
| Return on Assets | -29.31 | -51.90 | -67.85 | - |
| Return on Equity | -31.79 | -61.44 | -83.45 | - |
| Return on Invested Capital | -23.95 | -35.18 | -107.64 | -50.86 |
| Quick Ratio | 20.61 | 14.49 | 4.88 | 10.16 |
| Current Ratio | 20.61 | 14.49 | 4.88 | 10.16 |
Cash flow, annual
| Metric | TTM | 2025FY | 2024FY | 2023FY | 2022FY |
|---|---|---|---|---|---|
| Net Income | -109.52 | -75.27 | -61.69 | -47.26 | -40.24 |
| Depreciation | 0.61 | 0.65 | 0.67 | 0.58 | 0.12 |
| Other Funds (Non Cash) | 25.35 | 10.98 | 11.31 | 3.76 | 1.29 |
| Funds from Operations | -83.56 | -63.65 | -49.71 | -42.92 | -38.83 |
| Extraordinary Item | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Changes in Working Capital | 4.15 | -2.65 | -3.08 | -0.78 | 2.76 |
| Cash from Operating Activities | -79.41 | -66.30 | -52.79 | -43.70 | -36.07 |
| Capital Expenditures | -0.20 | -0.38 | -0.03 | -1.12 | -1.87 |
| Net Assets From Acquisitions | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sale of Fixed Assets and Businesses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Purchase or Sale of Investments | 108.03 | -118.37 | -126.89 | 28.47 | -27.39 |
| Purchase of Investments | -112.59 | -325.02 | -182.84 | -23.53 | -40.39 |
| Sale Or Maturity of Investments | 220.62 | 206.65 | 55.95 | 52.00 | 13.00 |
| Other Uses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Sources | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cash from Investing Activities | 107.82 | -118.75 | -126.91 | 27.35 | -29.26 |
| Cash Dividends Paid | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Change in Capital Stock | 4.63 | 205.71 | 178.97 | 0.03 | 110.86 |
| Repurchase of Common Pref Stock | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sale of Common Pref Stock | 4.63 | 205.71 | 178.97 | 0.03 | 110.86 |
| Proceedsfrom Stock Options | -0.58 | 202.07 | 178.83 | 0.00 | 110.79 |
| Issuance or Reduction of Debt, Net | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Change in Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Issuance of Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Reduction of Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Net Financing Active Other Cash Flow | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Financing Activities Uses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cash from Financing Activities | 4.63 | 205.71 | 178.97 | 0.03 | 110.86 |
| Net Change in Cash | 33.05 | 20.66 | -0.73 | -16.32 | 45.52 |
| Free Cash Flow | -79.61 | -66.67 | -52.81 | -44.81 | -37.94 |
| Preferred Dividends (Cash Flow) | - | 0.00 | 0.00 | 0.00 | 0.00 |
| Deferred Taxes & Investment Tax Credit | - | 0.00 | 0.00 | 0.00 | 0.00 |
Balance sheet, quarterly
| Metric | 2026Q3 | 2026Q2 | 2026Q1 | 2025Q4 | 2025Q3 | 2025Q2 |
|---|---|---|---|---|---|---|
| Cash & Short Term Investments | 224.59 | 211.03 | 216.15 | 235.88 | 248.33 | 262.57 |
| Short Term Receivables | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Inventories | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Current Assets | 3.94 | 5.10 | 4.81 | 5.54 | 4.00 | 4.17 |
| Total Current Assets | 228.53 | 216.13 | 220.96 | 241.42 | 252.33 | 266.75 |
| Net Property, Plant & Equipment | 7.92 | 8.34 | 8.75 | 9.15 | 9.31 | 9.64 |
| Total Investments and Advances | 26.17 | 58.19 | 74.74 | 75.38 | 77.63 | 75.66 |
| Intangible Assets | - | - | - | 0.00 | 0.00 | 0.00 |
| Deferred Tax Assets | - | - | - | 1.98 | - | - |
| Other Assets | 0.64 | 0.59 | 0.58 | 0.00 | 0.00 | 0.00 |
| Total Assets | 263.26 | 283.25 | 305.04 | 327.93 | 339.27 | 352.05 |
| Short Term Debt Incl. Current Port. of LT Debt | 1.43 | 1.38 | 1.32 | 1.27 | 1.22 | 1.17 |
| Accounts Payable | 1.05 | 0.52 | 2.11 | 0.77 | 1.48 | 0.91 |
| Other Current Liabilities | 13.94 | 8.88 | 6.34 | 9.67 | 7.15 | 5.47 |
| Total Current Liabilities | 16.42 | 10.78 | 9.78 | 11.71 | 9.85 | 7.55 |
| Long Term Debt | 6.32 | 6.69 | 7.05 | 7.41 | 7.75 | 8.07 |
| Provision for Risks Charges | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Deferred Tax Liabilities | - | - | - | 1.98 | - | - |
| Other Liabilities | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Total Liabilities | 22.74 | 17.47 | 16.83 | 21.10 | 17.60 | 15.62 |
| Non-Equity Reserves | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Preferred Stock - Carrying Value | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Common Equity | 240.52 | 265.77 | 288.21 | 306.83 | 321.67 | 336.43 |
| Total Shareholders Equity | 240.52 | 265.77 | 288.21 | 306.83 | 321.67 | 336.43 |
| Accumulated Minority Interest | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Total Equity | 240.52 | 265.77 | 288.21 | 306.83 | 321.67 | 336.43 |
| Total Liabilities & Stockholders Equity | 263.26 | 283.25 | 305.04 | 327.93 | 339.27 | 352.05 |
| Book Value Per Share | 5.32 | 5.88 | 6.39 | 6.86 | 7.23 | 7.62 |
| Tangible Book Value Per Share | 5.32 | 5.88 | 6.39 | 6.86 | 7.23 | 7.62 |
| Full-Time Employees | - | - | - | 59 | - | - |
| Price to Book Ratio | 0.70 | 6.88 | 5.84 | 5.69 | 3.86 | 2.17 |
| Return on Assets | -36.35 | -30.66 | -25.36 | -29.31 | -26.35 | - |
| Return on Equity | -38.96 | -32.34 | -26.74 | -31.79 | -28.07 | - |
| Return on Invested Capital | -13.13 | -10.97 | -9.07 | -6.50 | -6.16 | -5.24 |
| Quick Ratio | 13.92 | 20.05 | 22.60 | 20.61 | 25.61 | 35.33 |
| Current Ratio | 13.92 | 20.05 | 22.60 | 20.61 | 25.61 | 35.33 |
Cash flow, quarterly
| Metric | 2026Q3 | 2026Q2 | 2026Q1 | 2025Q4 | 2025Q3 | 2025Q2 |
|---|---|---|---|---|---|---|
| Net Income | -32.42 | -29.89 | -26.78 | -20.44 | -20.28 | -18.07 |
| Depreciation | 0.15 | 0.15 | 0.15 | 0.15 | 0.19 | 0.15 |
| Other Funds (Non Cash) | 7.36 | 7.18 | 6.84 | 3.96 | 2.96 | 2.16 |
| Funds from Operations | -24.90 | -22.55 | -19.78 | -16.32 | -17.13 | -15.76 |
| Extraordinary Item | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Changes in Working Capital | 6.18 | 0.33 | -2.06 | -0.30 | 1.90 | -2.40 |
| Cash from Operating Activities | -18.72 | -22.22 | -21.84 | -16.63 | -15.23 | -18.15 |
| Capital Expenditures | 0.00 | 0.00 | 0.00 | -0.20 | -0.09 | 0.00 |
| Net Assets From Acquisitions | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sale of Fixed Assets and Businesses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Purchase or Sale of Investments | 38.95 | 21.47 | 24.82 | 22.79 | 23.19 | -23.25 |
| Purchase of Investments | -11.35 | -33.03 | -25.33 | -42.88 | -54.14 | -56.42 |
| Sale Or Maturity of Investments | 50.30 | 54.50 | 50.15 | 65.67 | 77.33 | 33.17 |
| Other Uses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Sources | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cash from Investing Activities | 38.95 | 21.47 | 24.82 | 22.59 | 23.10 | -23.25 |
| Cash Dividends Paid | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Preferred Dividends (Cash Flow) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Change in Capital Stock | 0.33 | 0.75 | 1.89 | 1.66 | 1.97 | -0.31 |
| Repurchase of Common Pref Stock | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Sale of Common Pref Stock | 0.33 | 0.75 | 1.89 | 1.66 | 1.97 | -0.31 |
| Proceedsfrom Stock Options | -0.03 | -0.23 | -0.32 | 0.00 | 0.00 | -0.32 |
| Issuance or Reduction of Debt, Net | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Change in Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Issuance of Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Reduction of Long Term Debt | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Net Financing Active Other Cash Flow | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Other Financing Activities Uses | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Cash from Financing Activities | 0.33 | 0.75 | 1.89 | 1.66 | 1.97 | -0.31 |
| Net Change in Cash | 20.56 | -0.00 | 4.87 | 7.62 | 9.85 | -41.71 |
| Free Cash Flow | -18.72 | -22.22 | -21.84 | -16.83 | -15.32 | -18.15 |
Revenue breakdown
| Revenue split | - |
|---|
Short interest
shares short against float, oldest to newest| Settlement | Of float | Shares short | Float | Avg volume |
|---|---|---|---|---|
| 2026-10-30 | 17.88% | 4.2M | 23.6M | 2.27M |
| 2026-10-15 | 15.60% | 3.7M | 23.6M | 2.20M |
| 2026-09-30 | 14.58% | 3.8M | 26.0M | 2.14M |
| 2026-09-15 | 15.23% | 4.0M | 26.0M | 1.97M |
| 2026-08-31 | 16.22% | 4.3M | 26.5M | 1.80M |
| 2026-08-14 | 16.04% | 4.2M | 26.5M | 1.59M |
| 2026-07-31 | 15.75% | 4.2M | 26.7M | 464.51K |
| 2026-07-15 | 19.76% | 5.3M | 26.6M | 432.35K |
| 2026-06-30 | 20.82% | 5.5M | 26.5M | 433.09K |
| 2026-06-15 | 18.92% | 5.0M | 26.4M | 394.28K |
| 2026-05-29 | 17.61% | 4.6M | 26.3M | 383.07K |
| 2026-05-15 | 18.00% | 4.7M | 26.3M | 360.15K |
| 2026-04-30 | 16.42% | 4.2M | 25.8M | 356.34K |
| 2026-04-15 | 14.77% | 3.8M | 25.7M | 317.83K |
| 2026-03-31 | 15.00% | 3.8M | 25.0M | 295.68K |
| 2026-03-13 | 14.15% | 3.5M | 25.0M | 304.96K |
| 2026-02-27 | 13.38% | 3.4M | 25.0M | 303.39K |
| 2026-02-13 | 12.34% | 3.1M | 24.8M | 317.34K |
| 2026-01-30 | 12.57% | 3.1M | 25.0M | 283.05K |
| 2026-01-15 | 12.35% | 3.1M | 24.7M | 309.37K |
Option chain
expiry 2026-11-20| Type | Strike | Bid | Ask | Last | IV | Open int | Volume | Delta | Theta | Vega |
|---|---|---|---|---|---|---|---|---|---|---|
| call | 2.50 | 0.80 | 1.50 | 0.00 | 4.017 | 0.00 | 0.00 | 0.918 | -0.010 | 0.001 |
| call | 5.00 | 0.00 | 0.50 | 0.05 | 3.863 | 61.00 | 0.00 | 0.421 | -0.049 | 0.002 |
| call | 7.50 | 0.00 | 0.10 | 0.05 | 3.114 | 46.00 | 0.00 | 0.130 | -0.020 | 0.001 |
| call | 10.00 | 0.00 | 0.75 | 0.30 | 4.137 | 1.00 | 0.00 | 0.111 | -0.026 | 0.001 |
| call | 12.50 | 0.00 | 0.75 | 0.00 | 4.755 | 0.00 | 0.00 | 0.101 | -0.027 | 0.001 |
| call | 15.00 | 0.00 | 3.80 | 0.00 | 5.237 | 0.00 | 0.00 | 0.095 | -0.029 | 0.001 |
| put | 2.50 | 0.00 | 0.05 | 0.05 | 7.005 | 60.00 | 0.00 | -0.176 | -0.060 | 0.002 |
| put | 5.00 | 0.95 | 1.70 | 2.39 | 3.437 | 7.00 | 0.00 | -0.579 | -0.049 | 0.002 |
| put | 7.50 | 3.20 | 4.40 | 0.00 | 6.037 | 1.00 | 0.00 | -0.870 | -0.022 | 0.001 |
| put | 10.00 | 4.00 | 8.50 | 0.00 | 14.517 | 0.00 | 0.00 | -0.889 | -0.024 | 0.001 |
| put | 12.50 | 6.50 | 11.00 | 0.00 | 15.229 | 0.00 | 0.00 | -0.899 | -0.026 | 0.001 |
| put | 15.00 | 9.00 | 13.50 | 0.00 | 15.786 | 0.00 | 0.00 | -0.905 | -0.027 | 0.001 |
Latest SEC filings
30| Filed | Form | Description | Period | Link |
|---|---|---|---|---|
| 2026-11-10 | 10-Q | Quarterly report pursuant to Section 13 or 15(d) | 2026-09-30 | SEC |
| 2026-11-10 | 8-K | Current report | 2026-11-10 | SEC |
| 2026-11-09 | SCHEDULE 13G | SEC | ||
| 2026-09-21 | SCHEDULE 13D/A | SEC | ||
| 2026-09-21 | 4 | Statement of changes in beneficial ownership of securities | 2026-09-17 | SEC |
| 2026-09-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-09-17 | SEC |
| 2026-09-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-09-17 | SEC |
| 2026-09-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-09-17 | SEC |
| 2026-09-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-09-17 | SEC |
| 2026-09-17 | 144 | Filing for proposed sale of securities under Rule 144. | SEC | |
| 2026-09-14 | 8-K | Current report | 2026-09-09 | SEC |
| 2026-08-10 | 8-K | Current report | 2026-08-10 | SEC |
| 2026-08-06 | 10-Q | Quarterly report pursuant to Section 13 or 15(d) | 2026-06-30 | SEC |
| 2026-08-06 | 8-K | Current report | 2026-08-06 | SEC |
| 2026-07-09 | 4 | Statement of changes in beneficial ownership of securities | 2026-07-07 | SEC |
| 2026-07-09 | 4 | Statement of changes in beneficial ownership of securities | 2026-07-07 | SEC |
| 2026-07-07 | 4 | Statement of changes in beneficial ownership of securities | 2026-07-06 | SEC |
| 2026-07-06 | 144 | Filing for proposed sale of securities under Rule 144. | SEC | |
| 2026-07-02 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-30 | SEC |
| 2026-07-02 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-30 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 8-K | Current report | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
| 2026-06-18 | 4 | Statement of changes in beneficial ownership of securities | 2026-06-17 | SEC |
Insider activity by month
| Month | Bought | Buys | Sold | Sells |
|---|---|---|---|---|
| 2026-11 | 0 | 0 | 0 | 0 |
| 2026-10 | 0 | 0 | 0 | 0 |
| 2026-09 | 0 | 0 | 21.84M | 1 |
| 2026-08 | 0 | 0 | 0 | 0 |
| 2026-07 | 0 | 0 | 8.16M | 3 |
| 2026-06 | 0 | 0 | 10.54M | 2 |
| 2026-05 | 0 | 0 | 26.74M | 8 |
| 2026-04 | 0 | 0 | 50.83M | 10 |
| 2026-03 | 0 | 0 | 347.02K | 1 |
| 2026-02 | 0 | 0 | 2.76M | 4 |
| 2026-01 | 0 | 0 | 10.00M | 1 |
| 2025-12 | 0 | 0 | 3.55M | 9 |
| 2025-11 | 0 | 0 | 16.33M | 11 |
Institutional holders
| Manager | % owned |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 21.94% |
| TPG GP A, LLC | 14.39% |
| VIKING GLOBAL INVESTORS LP | 7.08% |
| Atlas Venture Life Science Advisors, LLC | 6.63% |
| ORBIMED ADVISORS LLC | 5.66% |
| Enavate Sciences GP, LLC | 5.49% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.54% |
| JPMORGAN CHASE & CO | 3.30% |
| BlackRock, Inc. | 3.27% |
| Aberdeen Group plc | 2.97% |
Funds
| Fund | % owned |
|---|---|
| VANGUARD TOTAL STOCK MARKET INDEX FUND | 2.07% |
| PGIM Jennison Health Sciences Fund | 2.06% |
| State Street(R) SPDR(R) S&P(R) Biotech ETF | 1.43% |
| JPMorgan Small Cap Growth Fund | 1.16% |
| iShares Russell 2000 ETF | 1.07% |
| Eventide Healthcare & Life Sciences Fund | 1.05% |
| T. Rowe Price Health Sciences Fund, Inc. | 0.64% |
| Fidelity Small Cap Index Fund | 0.45% |
| abrdn Healthcare Investors | 0.45% |
| iShares Biotechnology ETF | 0.41% |
OakChart. SION. Cached 15 minutes.